The phase where collagen synthesis and granulation tissue form is which?

The phase where collagen synthesis and granulation tissue form is which?

• A. Hemostasis and inflammation
• B. Epitheliazation
• C. Proliferation
• D. Remodeling

Answer: (C)

The proliferative phase. In this stage, fibroblasts migrate into the wound and lay down collagen (beginning with type III) to form a new extracellular matrix, and capillaries grow into the area to create granulation tissue. Epithelial cells also begin to migrate over this bed, re-epithelializing the wound. This combination of collagen synthesis, granulation tissue formation, and early neovascularization is the hallmark of the proliferative phase, which bridges the initial inflammation to the later remodeling that strengthens the tissue. Hemostasis and inflammation occur earlier, focusing on clotting and immune cell cleanup, while remodeling happens later as the collagen is reorganized and tensile strength increases.

The proliferative phase. In this stage, fibroblasts migrate into the wound and lay down collagen (beginning with type III) to form a new extracellular matrix, and capillaries grow into the area to create granulation tissue. Epithelial cells also begin to migrate over this bed, re-epithelializing the wound. This combination of collagen synthesis, granulation tissue formation, and early neovascularization is the hallmark of the proliferative phase, which bridges the initial inflammation to the later remodeling that strengthens the tissue. Hemostasis and inflammation occur earlier, focusing on clotting and immune cell cleanup, while remodeling happens later as the collagen is reorganized and tensile strength increases.