Pulsed ultrasound on injury response process is associated with which cellular mediator?

Pulsed ultrasound on injury response process is associated with which cellular mediator?

• A. Mast cells
• B. Lymphocytes
• C. Macrophages
• D. Platelets

Answer: (A)

Pulsed ultrasound interacts with the injury response through early inflammatory mediators released by mast cells. The non-thermal, mechanical effects of pulsed ultrasound can stimulate resident mast cells in connective tissue to degranulate, releasing histamine (along with other mediators). Histamine then causes vasodilation and increased vascular permeability, helping fluid and immune cells reach the injury site quickly and kick-start the healing process. Among the options, mast cells are the best fit because they are the immediate source of these inflammatory mediators that respond to mechanical stimulation. Lymphocytes, macrophages, and platelets are involved in later or different aspects of healing, not the immediate mediator most closely linked to the acute ultrasound–tied response.

Pulsed ultrasound interacts with the injury response through early inflammatory mediators released by mast cells. The non-thermal, mechanical effects of pulsed ultrasound can stimulate resident mast cells in connective tissue to degranulate, releasing histamine (along with other mediators). Histamine then causes vasodilation and increased vascular permeability, helping fluid and immune cells reach the injury site quickly and kick-start the healing process. Among the options, mast cells are the best fit because they are the immediate source of these inflammatory mediators that respond to mechanical stimulation. Lymphocytes, macrophages, and platelets are involved in later or different aspects of healing, not the immediate mediator most closely linked to the acute ultrasound–tied response.