During proliferation, what is occurring?

During proliferation, what is occurring?

• A. Blood vessel formation, capillary bedding, capillary arcade formation, and collagen is being formed
• B. WBC infiltration at the wound site
• C. Fibroblast apoptosis
• D. Tissue necrosis

Answer: (A)

During the proliferation phase, the wound is rebuilt with new tissue. The key events are the growth of new blood vessels (angiogenesis), forming a capillary bed and capillary arcade within granulation tissue, and the synthesis of extracellular matrix by fibroblasts, notably collagen, to fill the wound and provide strength. This vascular and ECM activity supplies nutrients and scaffolds for repair as the tissue sites are populated with new cells. In contrast, white blood cell infiltration happens mainly during the inflammatory phase as the body responds to injury, fibroblast apoptosis would reduce the cells needed for matrix deposition, and tissue necrosis signifies tissue death rather than constructive repair. Therefore, the combination of new vasculature and collagen deposition precisely reflects what occurs during proliferation.

During the proliferation phase, the wound is rebuilt with new tissue. The key events are the growth of new blood vessels (angiogenesis), forming a capillary bed and capillary arcade within granulation tissue, and the synthesis of extracellular matrix by fibroblasts, notably collagen, to fill the wound and provide strength. This vascular and ECM activity supplies nutrients and scaffolds for repair as the tissue sites are populated with new cells. In contrast, white blood cell infiltration happens mainly during the inflammatory phase as the body responds to injury, fibroblast apoptosis would reduce the cells needed for matrix deposition, and tissue necrosis signifies tissue death rather than constructive repair. Therefore, the combination of new vasculature and collagen deposition precisely reflects what occurs during proliferation.